Skip Navigation


The European Journal of Orthodontics Advance Access originally published online on December 22, 2005
The European Journal of Orthodontics 2006 28(3):241-246; doi:10.1093/ejo/cji100
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
28/3/241    most recent
cji100v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (4)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Yamaguchi, M.
Right arrow Articles by Kasai, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamaguchi, M.
Right arrow Articles by Kasai, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Relationship between substance P and interleukin-1ß in gingival crevicular fluid during orthodontic tooth movement in adults

Masaru Yamaguchi, Mizuho Yoshii and Kazutaka Kasai

Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan

Address for correspondence Masaru Yamaguchi, Department of Orthodontics, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo, Chiba 271-8587, Japan. E-mail address: dai{at}mascat.nihon-u.ac.jp

Metabolism by peptidases plays an important role in modulating the levels of biologically-active neuropeptides, while that of substance P (SP), a component of gingival crevicular fluid (GCF), may potentiate the inflammatory process in orthodontic tooth movement. The aim of this study was two-fold: (1) to investigate GCF levels of SP and interleukin-1ß (IL-1ß) during human orthodontic tooth movement, and (2) to determine the correlation coefficients between SP and IL-1ß levels in the GCF.

The subjects were 3 males, with a mean age of 21.3 ± 2.8 years old, and 6 females, with a mean age of 23.1 ± 2.4 years, undergoing orthodontic movement of a single tooth, with the contralateral tooth used as the control. GCF was sampled at the control and treatment (compression) sites before and 1, 4, 8, 24, 72, 120, and 168 hours after initiation of orthodontic treatment. Prevention of plaque-induced inflammation allowed assessment of the dynamics of mechanically stimulated SP and IL-1ß levels in the GCF, which were determined using enzyme-linked immunosorbent assay (ELISA) kits.

GCF levels of SP and IL-1ß for the treated teeth were significantly higher (P < 0.001) than for the corresponding control teeth from 8 to 72 hours, and peaked at 24 hours.

These results show that the amounts of SP and IL-1ß in GCF increase with orthodontic tooth movement, and indicate that such increases may be involved in inflammation in response to mechanical stress.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Orthod.Home page
N. Akram and J. E. Harrison
Evidence-based orthodontics
J. Orthod., June 1, 2008; 35(2): 126 - 131.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.