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The European Journal of Orthodontics Advance Access published online on October 11, 2009
The European Journal of Orthodontics, doi:10.1093/ejo/cjp108
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© The Author 2009. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Does orthodontic tooth movement cause an elevation in systemic inflammatory markers?

J. K. MacLaine*, A. B. M. Rabie*, R. Wong* and A. Blechman**

* Orthodontics, Faculty of Dentistry, University of Hong Kong China
** Orthodontics, Columbia University College of Dental Medicine, New York, USA

Address for correspondence Professor B. Rabie, Department of Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China E-mail: rabie{at}hkusua.hku.hk


  Abstract

The aim of this study was to evaluate the effects of orthodontic treatment on systemic levels of the inflammatory markers, C-reactive protein (CRP), tumour necrosis factor-{alpha} (TNF-{alpha}), and interleukin-6 (IL-6). The study group comprised 11 girls and 6 boys (mean age 13.1 years) treated with fixed appliances and distalizing headgear. Venous blood samples were taken from the cubital vein of each subject before treatment (T0) and then at three further time points during treatment (T1–T3), 2 months apart. The sera from these blood samples were analysed using enzyme-linked immunosorbent assay (ELISA) assay technology for CRP, TNF-{alpha}, and IL-6 concentration levels. Data were compared between baseline and subsequent sequential time points using a Mann–Whitney test for non-normally distributed variables.

The results showed that there was no significant elevation of any of the three inflammatory markers at any of the time points. This research provides evidence that conventional orthodontic treatment is not associated with a systemic immune response in the factors investigated.


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