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The European Journal of Orthodontics 1987 9(1):24-32; doi:10.1093/ejo/9.1.24
© 1987 by European Orthodontic Society
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Localization of epidermal growth factor receptors in mouse incisors and human premolars during eruption

Irma Thesleff, Anna-Maija Partanen and Leena Rihtniemi

Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki SF-00280 Helsinki, Finland

Irma Thcsleff Institute of Dentistry University of Helsinki Mannerheimintie 172 SF-00280 Helsinki Finland

Epidermal growth factor (EGF) binding cells were localized in the apical parts of mouse incisors and erupting human premolars. The apical, non-mineralized tissue was dissected, incubated with 125Iodine-labelled EGF, washed and processed for autoradiography. After development the tissue sections were observed in the light microscope. In mouse incisors, heavy labelling was observed in the mesenchymal tissue at the apical foramen as well as in the walls of blood vessels. Intense labelling was seen also in epithelial cells in the cervical loop area and in the tissue surrounding the root sheath epithelium. No EGF binding was detected in the pulpal mesenchyme nor in the odontoblasts and ameloblasts. In the human premolars no label was seen in the pulpal tissue whereas relatively abundant labelling was observed in the dental follicle. This study is the first demonstration of EGF binding cells in erupting mouse and human teeth. The marked differences between various cell populations in the amount of binding of EGF imply that these cells may differ in their responsiveness to EGF.


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