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The European Journal of Orthodontics 1996 18(1):237-243; doi:10.1093/ejo/18.1.237
© 1996 by European Orthodontic Society
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The influence of transforming growth factor ß1 on the development of embryonic mouse long bones

C. M. J. Scheijmans*,, S. C. Dieudonné**, B. Prahl-Adnersen* and E. H. Burger**

*Department of Orthodontics, Academic Centre for Dentistry, Amsterdam The Netherlands
**Department of Oral Cell Biology, Academic Centre for Dentistry, Amsterdam The Netherlands

Address for correspondence Christiane Scheijmans, Department of Orthodontics, Academic Centre for Dentistry, Louwesweg 1, 1066 EA Amsterdam, The Netherlands

Transforming growth factor ß1 (TGF-ß1) is an important regulator of bone metabolism, and is found in large quantities in embryonic and adult bone tissue. The influence of TGF-ß1 on chondro-osteogenesis was studied. In organ cultures of developing long bone rudiments of embryonic mice, growth and development of the various cartilaginous and osseous compartments were investigated by morphometric analysis and autoradiography after [3H]-thymidine labelling.

TGF-ß1 (I ng/ml) inhibited both chondrogenesis and osteogenesis, and also inhibited matrix calcification. The effect was greatest in cell populations with the highest proliferation rate. It was noticed that the bone collar formation was inhibited. This may be due to an inhibition of osteoblast proliferation or differentiation, but it seems more likely to be an inhibition of the manufacture of matrix substance. These data suggest that TGF-ß1 may be an important regulator of embryonic bone development.


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